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中国癌症防治杂志

中国癌症防治杂志 ›› 2011, Vol. 3 ›› Issue (3): 242-245.doi: 10.3969/j.issn.1674-5671.2011.03.18

• 临床研究 • 上一篇    下一篇

冷基循环微波消融治疗晚期周围型肺癌的疗效观察 

李发强, 冯立冬, 李本全, 张胜, 王道军, 刘阿海, 詹香草, 靳桂红, 王艳霞   

  1. 河南焦煤焦煤中央医院肿瘤科  
  • 出版日期:2011-09-25 发布日期:2011-10-17

Clinical observation of microwave ablation with water circulation cooling system for treating advanced peripheral lung cancer

LI Fa-Qiang, FENG Li-Dong, LI Ben-Quan, ZHANG Sheng, WANG Dao-Jun, LIU A-Hai, ZHAN Xiang-Cao, JIN Gui-Hong, WANG Yan-Xia   

  • Online:2011-09-25 Published:2011-10-17

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摘要： 目的 探讨冷基循环微波消融技术对周围型肺癌治疗的可行性和临床疗效。方法 选择36例晚期不能手术的周围型肺癌患者，先给予常规化、放治疗控制病情后，再采用冷基循环微波消融技术对残余肿瘤病灶进行消融减瘤、减症治疗，以期获得更好的远期生存结果和生活质量。结果 手术完成36例，消融肿瘤病灶42个，完成率100%。术后3d咳嗽、咳痰、咯血和胸痛等症状缓解33例，缓解率91.67%；术后3~6个月，42个肿瘤病灶中完全坏死、吸收36个（85.71%），大部分坏死、吸收（≥90%）4个（9.52%），坏死、吸收50%~70%的病灶2个(4.76%)；瘤体直径为0~3cm，比术前缩小2.5~5cm，平均缩小4cm。疗效评价：CR 31例（86.11%），PR 4例（11.11%），NC 1例（2.78%），PD 0例；总缓解率97.22%；临床获益率36例(100%)；总生存期10~46个月，中位生存期28个月。结论 冷基循环微波消融技术可以作为晚期周围型肺癌姑息治疗的有效方法。

关键词: 微波消融治疗, 肺癌, 疗效

Abstract: Objective To explore the feasibility and clinical effect of the microwave ablation technology with water circulation cooling system on treating advanced peripheral lung cancer. Methods 36 patients with inoperable advanced peripheral lung cancer were treated firstly with chemotherapy and radiotherapy. The residual tumors were then treated by microwave ablation with water circulation cooling system. Results  Operations were completed in 36 patients，the completion rate was 100%. 3 days after treatment，33 cases showed remission of cough，sputum，hemoptysis，chest pain and other symptoms，the remission rate was 91.67%3~6 months after treatment，with enhanced CT on 42 tumors，36 (85.71%) showed complete necrosis absorption，4 (9.52%) expressed as most (≥ 90%) necrotic absorption，2 showed 50% to 70% necrotic absorption. Tumor diameters were reduced 2.5 to 5cm，with the average of 4cm. 31 (86.11%) cases obtained complete remission，4 (11.11%) cases obtained partial remission and 1 (2.78%) case had no change. The total remission rate was 97.22% and clinical benefit rate was 100%，the overall survival time was 10 to 46 months，and the average survival time was 28 months.ConclusionMicrowave ablation technique with water circulation cooling system can be used as a palliative treatment for inoperable advanced peripheral lung cancer.

Key words: Microwave ablation, Lung cancer, Treatment effect